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Concurrently, depression affects approximately 300 million people globally, with years lived with disability accounting for 37.3% of all mental disorders, rendering it a leading cause of disability (Yun et al., 2024)

In addition, it was found that in 12-O-tetradecanoylphorbol-13-acetate (2.5 g/ear)-induced ear edema mouse models, L-theanine could downregulate the expression of platelet endothelial adhesion molecule-1 (PECAM-1) and decrease the production of pro-inflammatory factors, including IL-1, tumor necrosis factor-alpha (TNF-), and COX-2, which were significantly expressed in neutrophils, thus improving the infiltration and activation of neutrophils (30)

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