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Compared with SGLT2i alone, combination of SGLT2i with semaglutide OW T2D was significantly associated with 49% lower risk of ischemic stroke (HR, 0.51

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Weekly Schedule Example Option A (standard): 1 mL once weekly 10 doses (10 weeks) Option B (enhanced): 1 mL twice weekly 10 doses (5 weeks) Option C (light): 0.5 mL once weekly 20 doses (20 weeks) 4

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Conducted under GLP guidelines, this stage plays a key role in regulatory submissions such as IND

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