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This dual activation leads to improved insulin secretion in response to elevated blood glucose levels, while also reducing glucagon levels, thereby optimizing blood sugar control

According to the 2025 KFF Employee Health Benefits Survey: Nearly 20% of all large employers (200 or more employees) said that their largest health plan covers GLP-1 drugs used primarily for weight loss

In this context, Figure 1 illustrates how GLP-1 RAs activate the GLP-1R, subsequently initiating key intracellular signaling pathways such as Epac/PI3K/Akt, cAMP/PKA, and ERK/MAPK