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The theory of the origin of sleep which has gained the widest credence is the one that attributes it to anemia of the brain The idea behind this supposition has been that, as the day draws to an end, the circulatory mechanism becomes fatigued, the vasomotor center exhausted, the tone of the blood vessels deficient, and the energy of the heart diminished, and thus is the circulation to the cerebral arteries lessened. NATURE, May 5th, 1898

Furthermore, meta-analyses of microbiome datasets have identified inflammation-associated microbial features that can discriminate PD patients from controls with reasonable accuracy using predictive modeling approaches

Bays HE, Ballantyne CM, Kastelein JJ, Isaacsohn JL, Braeckman RA, Soni PN

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