tirzepatide and crohn's disease COMMIT-CD: A Phase 3b trial evaluating the efficacy & safety of concomitant use of a dual GLP-1/GIP receptor agonist & IL-23p19 antagonist in adult participants with moderately to severely active GLP-1 for Crohn's Disease: Current

Clin J Oncol Nurs 2017;21(5):629-632 4

It is not suitable for type 1 diabetes, diabetic ketoacidosis, or as firstline monotherapy when diet and exercise alone have not been evaluated

Endocrine regulation of central GLP-1 secretion As discussed above, in addition to enteroendocrine L-cells, GLP-1 is also produced in a discrete set of non-TH-positive neurons in the caudal portions of the NTS [86,148,[346], [347], [348]], and these hindbrain GCG + positive neurons are the primary source of endogenous brain GLP-1 [90]

Calculate the recovery by comparing the measured value with the expected amount of GLP-1 in the sample