The National Institute for Health and Care Excellence (NICE) provides guidance on the use of GLP-1 receptor agonists in guideline NG28, recommending them for type 2 diabetes in specific contexts, such as when other therapies have proven inadequate, particularly in people with higher BMI or cardiovascular risk factors
- cerebral or cardiac ischaemia episodes during the past 6 months
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The expression of p62 competitively binds to Keap1 to prevent NRF2 degradation, which promotes cell resistance to ferroptosis (Sun et al., 2016)
