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Results of IVIP T-cell assays As previously mentioned, the low incidence of observed clinical immunogenicity associated with TPT may be attributed to (a) TPT being derived from the N-terminus of human PTH (an endogenous peptide) and/or (b) due to the presence of a potential Treg epitope in the N-terminus that is cross-conserved with -tubulin and other self-proteins

Email: [email protected] ORCID: Affiliation: 16 Centro de Investigacin Biomdica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, 28031 Madrid, Spain 17 Departament de Biochemistry and Molecular Biomedicine, University of Barcelona, 08028 Barcelona, Spain 18 Institut de Qumica Terica i Computacional (IQTCUB), School of Chemistry, University of Barcelona, 08028 Barcelona, Spain These authors contributed equally to this work

doi:10.1038/eye.2014.144 36