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Our proposal would help mitigate the risk of paying substantial shared savings to an ACO where the savings are attributable to the variability in benchmark calculations rather than actual program performance as can be the case for ACOs with fewer than 5,000 assigned beneficiaries in one or both of benchmark years 1 and 2 that are susceptible to performance variability

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Personalized GLP-1 Therapy: Genetic Factors That Shape Your Weight Loss Response Not everyone responds identically to semaglutide because genetic variations in appetite-regulation pathways influence medication effectiveness