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Kisspeptin Kisspeptin has a more indirect effect on local immune tone, primarily regulating the reproductive hormone axis via stimulation of GnRH release

These findings suggest that while FOXO4 is involved in the senescence pathway, it also plays a role in maintaining the viability of senescent Leydig cells by suppressing their apoptotic response, which could contribute to the accumulation of senescent cells [1]

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As oestrogen drops during perimenopause and menopause, so does this built-in protection