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2021;33:833-44.e5

The therapeutic categories applied to this years analysis are: -Dopaminergic symptom relief therapies (MOA) apply to ST agents that either restore, replace or mimic the neurotransmitter dopamine, and include the following subcategories: - DA agonist - Levodopa (LD) reformulation - DA-ST Other -Non-dopaminergic symptom relief therapies (MOA) applies to ST agents that target neurotransmitter systems other than dopamine and include: - Adrenergic - Cholinergic - Glutamatergic - Serotonergic - Non-DA-ST Other - Anti-inflammatory (MOA) agents seeking to reduce inflammatory processes

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