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In the case of ischemic stroke, reactive astrocytes also contribute to BBB permeability through the Wnt/-catenin pathway as demonstrated in an Nhe1 conditional knockout mouse model 119

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The VEGF monoclonal antibody, ranibizumab, significantly improved synovial inflammation in CIA rats and was superior to the IL-6 monoclonal antibody, tocilizumab, in terms of anti-bone destruction (271)

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