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The miRNA duplex is loaded into a silencing complex that contains an Argonaute protein, and eventually, the mature single-stranded miRNA is retained by the Argonaute to target substrate mRNAs (Matranga et al, 2005

Key Benefits Highly effective in treating severe, cystic, nodular, and treatment-resistant acne Long-term results with a significant reduction in breakouts even after discontinuation Designed for customized dosing in low-dose acne treatment regimens Reduces inflammation, sebum production, and clogged pores Helps minimize the formation of permanent scars associated with nodular acne Ideal form for starting patients slowly or for maintenance treatment Suitable for weight-based dosing and titration Lower risk of side effects compared to higher-dose isotretinoin therapies Mechanism of Action Isotretinoin, the active ingredient in Isotretinoin 5 mg Capsules , is a retinoid that uniquely targets all four primary causes of acne: Reduces Sebum Production: Shrinks enlarged sebaceous glands to decrease oil output