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doi: 10.1242/jcs.103.4.931 118 BeglingerCDegenL

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The EVOKE and EVOKE+ research programmes tested an oral version of semaglutide the same substance used in the popular Ozempic/Wegovy injections but found it failed to slow disease progression in patients with early Alzheimers disease.i On December 1, 2025, Imperial led a trial using liraglutide a drug from the same GLP-1 class produced surprisingly promising results: nearly 50% less brain volume loss and an 18% slower decline in cognitive function.ii These promising results were published in Nature.iii So, what can we learn from these contrasting findings