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this was particularly evident for patients treated with once-weekly GLP-1 RAs at 12 months post-index, where a mean weight loss of 2.8 kg (95% CI 3.6, 2.1) was reported for adherent patients, whereas poor adherence was associated with a weight gain of 0.2 kg ( 0.5, 0.9) (Supplemental Fig

Tirzepatide Tirzepatide is a newer medication that works as a dual GIP/GLP-1 receptor agonist, targeting two hormones involved in appetite and blood sugar regulation

GLP-1 agonists inhibit TNF- and nuclear factor-kappa B (NF-B), thereby reducing pro-inflammatory cytokines

Collagen peptides show the most robust evidence when combined with resistance training, while growth hormone-releasing peptides demonstrate modest effects