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In addition, there is a hybrid receptor with components of the IR (one and one -chain) and the IGF-1R (one and one -chain), to which both insulin and IGF-1 can bind to, but with less affinity than that of their putative receptors [98100]

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Furthermore, 1905, which contains an i,i + 7 staple in place of E144 and E151, both of which are important for forming electrostatic interactions, performed poorly in SPR and FP assays (Supplementary Figs