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Tumor cells can destroy the nerve sheath in the process of PNI, which makes the nerve more sensitive to stimulation [35]

Risks for laser surgery include transient/permanent hyperpigmentation, hypopigmentation, and scarring

Unlike native IGF-1, which is rapidly bound and regulated by IGFBPs in circulation, IGF-1 LR3 was engineered to remain active longer, making it a useful tool for researchers studying sustained IGF-1 receptor signaling rather than the brief signaling windows native IGF-1 typically produces