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Tissue microarray (TMA) analysis demonstrated that PDHA1 was significantly overexpressed in cancerous tissues compared to adjacent normal tissues, with higher PDHA1 expression correlating with worse overall survival (OS), disease-free survival (DFS), and advanced Gleason scores (Fig

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QSSA was used in this iteration of the design to assume enzyme levels stayed constant, but further investigation of the induction of oxidative stress genes by ROS and how this might change enzyme concentrations would be of value

Syringe Units = Volume to Draw (mL) 100 = 1.0 mL 100 = 100 units NAD+ Dosing Profile (100 mg/mL Concentration) 50 mg Dose: Draw 50 units (0.5 mL)