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Risk Stratification: Who Should Proceed with Caution Not all patients with gallstones face the same risk during GLP-1 therapy

Though subsequent events after protein binding were cause for controversy initially (detailed in the section on ferroptosis), progress in resolving this issue was made when it was shown that an oxidant stress was not observed during metabolism of APAP [23, 24] but only after the drug metabolism phase was completed, and that the oxidant stress was located within mitochondria [25, 26]

Although the absolute risk remains relatively low, studies show a modest but consistent increase in gallstones and cholecystitis among treated patients compared to placebo

As a botanical flavone with strong antioxidant properties and abundant in multiple plants (Zhang et al., 2020), the extraction of myricitrin has been streamlined, with methods of high-level production under exploration (Geng et al., 2023)