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Notably, periportal assembloids outperformed differentiated h-HepOrgs in both urea production and gluconeogenesis (both of which are portal functions), while the drug-metabolizing capacity associated with pericentral hepatocytes was less pronounced than in hepatocyte organoids, in line with their more portal-like nature (Fig

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doi: 10.1101/2021.03.11.21253225 199 YelinDMargalitIYahavDRunoldMBruchfeldJ