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In individuals with obesity, the brain's reward centres may respond more intensely to food cues, whilst satiety signals may become blunted

Journal of Cellular Physiology, 234 (2), 13001312

2,3 The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb.) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb.) for the placebo group which was statistically significant