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Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling

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The method of claim 1 , wherein the PDE-5 inhibitor is administered prior to administration of PT-141

Ammonium accumulation enhances the cellular antioxidant capacity by activating a series of enzymes and pathways, such as glutamine synthetase, leading to the production of antioxidant compounds such as GSH