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MC1R signalling peaks 46 hours after subcutaneous injection, which is the optimal window for melanocyte responsiveness to UV photons

When bypassed via injection, or when very high concentrations are used topically over large surface areas, this regulatory mechanism is skipped

Portion sizes naturally decrease, and many patients report eating 3050% less than baseline without feeling deprived

Clinical data, including body composition analysis from the SURMOUNT-1 trial, confirms that tirzepatide produces reductions in both total body fat and visceral (abdominal) fat, the type most closely associated with metabolic health risks