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doi: 10.1016/j.chest.2020.12.034

Rhonda Patrick That said, resveratrol may help prevent cancer by reducing IGF-1, which is associated with tumor proliferation (at large doses of 1-2.5 g/day) Resveratrol is a Calorie Restriction Mimetic Resveratrol works mainly through sirtuin activation (sirtuins are a class of proteins that plan an essential role in aging and keeping cells healthy) Sirtuin activation mimics many of the longevity benefits of caloric restriction (and thus, resveratrol is a caloric restriction mimetic) In mice, resveratrol supplementation resulted in several physiological changes typically seen with caloric restriction, such as reduced IGF-1 and increased AMP-kinase activity (Study) As a caloric restriction mimetic, resveratrol promotes autophagy (Study) Autophagy is the process by which cells (or cellular components) eat themselves under conditions of nutrient deprivation (AKA fasting)

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