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Additional authors contributed to specific experiments, data analysis, and manuscript preparation

Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (270, 271), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (170, 209, 258, 259, 272, 273)

Novo Nordisk has successfully trialled a daily pill version of Wegovy (oral semaglutide) specifically for weight loss in 25mg and 50mg doses

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