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Finally, with typically older, multi-morbid, obese patients the primary target segment for muscle-preserving therapies, long-term safety and tolerability data, including in polypharmacy situations, are a key prerequisite for their wider adoption, to address lingering concerns about some of the mechanisms of action being explored

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Yet, they are a recognised side effect, especially in the early stages or during dose increases

While manufactured forms of semaglutide (e.g