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The STEP 1 trial (published in the New England Journal of Medicine) documented mean weight reductions of 14.9% with once-weekly semaglutide 2.4 mg compared to 2.4% with placebo, with corresponding improvements in waist circumference of approximately 13.5 cm with semaglutide versus 4.1 cm with placebo after 68 weeks

Despite positive preclinical outcomes, Dapiglutides safety and efficacy had not previously been validated in patients with obesity

addressing stress is one of the few levers you can use without changing medication

Brunner went on to say, I do question whether in resolving the shortage FDA has taken into account demand for the compounded drug the number of patients wholl need to be transitioned from compounded version to FDA-approved version