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On February 6, FDA announced its intention to take decisive enforcement action against non-FDA-approved compounded GLP-1 drugs, specifically identifying restrictions on GLP-1 active pharmaceutical ingredients (APIs) used in mass-marketed compounded products

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In the phase 3 TRANSCEND-T2D-1 diabetes trial (537 adults with recent-onset type 2 diabetes), retatrutide reduced HbA1c by up to 2.0% and produced 16.8% weight loss at 40 weeks, with about 90% of participants reaching an HbA1c below 7%