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One subject with severe RI (who did not have type 2 diabetes, but had experienced nausea, vomiting, and decreased appetite from the dosing day) had two major hypoglycemic events, one subject with moderate RI and one with ESRD experienced minor hypoglycemia, and two subjects in the moderate RI group experienced symptoms-only hypoglycemia

These discrepancies may be explained in part by the fact that while in most systems versions of CSD mimic the effects of endogenous CAV-1, in some systems they act as competitors of the activity of endogenous CAV-1 31,32,34,35,36

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By improving electron flow through the respiratory chain and reducing redox bottlenecks, NIR and methylene blue may help stabilize neuronal energy production in these metabolically fragile networks