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Transferred intratumoral OT-1 GPX4 cKO CD8 + T cells displayed a similar exhausted-like phenotype (expressing PD-1 and Lag-3) (Supplemental Figure 1M) but an increased stem-like phenotype (expressing Ly108 and CD69) (Supplemental Figure 1N) compared with control CD8 + T cells

Direct oxidation of GSH to GSH through free radical intermediates formed from 15-HpETE-PE before it is metabolized could also occur

Copper is an essential cofactor for superoxide dismutase (SOD), a primary antioxidant enzyme, and GHK-Cu has been studied in models examining oxidative stress mitigation

Understanding Glutathiones Role in Redox and Neurotransmission Systemic inflammation and oxidative stress have been observed alongside depressive disorders and certain anxiety-related presentations