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18% on placebo Growth concern / Long-term effects on linear growth, bone mineral density, and pubertal timing remain unstudied in pre-pubertal children Guideline position / The 2023 AAP Clinical Practice Guideline recommends pharmacotherapy starting at age 12, not younger Dose escalation schedule / The standard 16-week titration (0.25 mg to 2.4 mg weekly) has only been studied in patients aged 12 and above FDA Labeling: What Wegovy Is and Is Not Approved For in Children Wegovy received its initial FDA approval in June 2021 for adults with obesity (BMI of 30 or greater) or overweight (BMI of 27 or greater) with at least one weight-related comorbidity [1]

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It was observed that HUVECs treated with T-MNS (ICG) exhibited considerably stronger fluorescent signals compared to those treated with MNS (ICG) and NanoSU6668 (ICG) after a 6 h treatment period (Fig