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Semaglutide is a reasonable starting point for patients who need moderate weight loss support, have type 2 diabetes or prediabetes, or prefer a medication with a longer track record and well-established safety data
An example of such a drug is Lanifibranor, a pan-PPAR (peroxisome proliferatoractivated receptor) agonist, which affects crucial metabolic, inflammatory, and fibrogenic processes in NASH development (110)
Retinal pigment epithelium and monocytes' mitochondrial control of ferroptosis and its relevance to age-related macular degeneration
It also reduces glucagon production in the liver (glucagon is a storage form of glucose), preventing after-meal blood sugar spikes and improving insulin sensitivity
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