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Q.23 Administration of primaquine causes severe hemolytic anemia because it (A) increases the demand for NADPH to a level that cells cant meet (B) decreases the demand for NADPH (C) inactivates glutathione peroxidase of erythrocytes (D) increases reduced glutathione level of erythrocytes Primaquine administration causes severe hemolytic anemia primarily in individuals with G6PD deficiency due to oxidative stress overwhelming cellular defenses

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310,311 HMGCR is an ER membraneanchored protein responsible for catalyzing the rate-limiting step of sterol biosynthesis, namely, the reduction of -hydroxy -methylglutaryl-CoA (HMG-CoA) to mevalonate, a key intermediate in the synthesis of cholesterol and nonsterol isoprenoids, such as geranylgeranyl pyrophosphate (GGpp)

Ng 2002 Preclinical data in obese Zucker rats confirmed that 500 mcg/kg/day by intraperitoneal injection for 18 days preserved insulin sensitivity, unlike intact hGH