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16:00 Comparing Novos Triple to Retatrutide Analysis of weight loss percentages versus Lillys retatrutide data and the caution required when comparing across trials

A 2025 meta-analysis found no increase in depression or suicidality with GLP-1 medications versus placebo

Batsis, Prado, and colleagues, writing in Annals of Internal Medicine , applied prespecified benchmarks for expected muscle-related losses about 25% of total weight loss for FFM or lean soft tissue measured by BIA or DXA, and about 15% for skeletal muscle measured by CT or MRI

27 The mean eGFR was 62 ml/min/1.73 m, and 76% of patients had NYHA class II symptoms