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Due to its negative charge, melanin interferes with the action and efficacy of endogenous antimicrobial peptides and antifungals used to treat infection from C

For the GLP-1R V229A, however, we observed a higher proportion of receptors pre-existing as higher order oligomers under vehicle conditions, with no further increases after exendin-4 stimulation, indicating that the mutant receptor has a higher clustering propensity in the inactive state