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Because a critical step in the replication and transcription of SARS-CoV-2 requires the formation of a stable complex of the SARS-CoV-2 helicase (nsp13) and holo-RNA-dependent RNA polymerase (RdRp) 25 , we investigated the effect of clofazimine on this step, and found that clofazimine inhibited the unwinding activity of nsp13 using either a double-stranded DNA or double-stranded RNA substrate (Fig

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Metabolic disorders exhibit strong inflammatory underpinnings and vice versa, inflammation is associated with metabolic alterations