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What This Means Practically For patients with Type 2 diabetes, these findings have practical implications: First-line treatment recommendation: Major diabetes guidelines now recommend GLP-1 agonists as first-line treatment (alongside or instead of metformin) for patients with established cardiovascular disease

Of note, most of the pharmacological testing of these GLP1-based compounds has been implemented so far in male models of obesity 33,34,35,48 , with limited insight into their effects in female-specific metabolic conditions