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DRM reports receiving research support from Janssen, serving on advisory boards and as a consultant for Novo Nordisk, Novartis, Eli Lilly, Sanofi-Aventis, Janssen and Servier, and giving lectures for Novo Nordisk, Servier, Sanofi-Aventis, Eli Lilly, Novartis and Janssen

[DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted] 5.Bingham J.R., Kniery K.R., Jorstad N.L., Horkayne-Szakaly I., Hoffer Z.S., Salgar S.K

On the other hand, the glycerol-3-phosphate de-hydrogenase shuttle comprises cytosolic Nicotinamide adenine dinucleotide link G3PDH (Gpd1/2), and membrane-bound G3P

Increased MMP-2 and MMP-9 expression and activity can affect BBB permeability by proteolysis of extracellular matrix and structural proteins in brain endothelial cells, increasing the BBB breakdown (Figure 2) (Yang et al., 2007