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Dixon's group demonstrated that the GSH exporter MRP1 sensitizes HPA1 erastin-treated cells to ferroptosis and concordantly, MRP1 inhibition leads to a retention of GSH and leads to ferroptosis resistance (58)

According to the FDA, these medications are approved for people who: Have a BMI* of 30 or higher (classified as obesity), or Have a BMI of 27 or higher (overweight) and at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol *While BMI isnt a perfect measurement, its one tool health care providers use to help assess overall health risks

10.1016/j.biochi.2021.10.017 47 MartinsF

Micronutrients and Monitoring Because patients are consuming less food overall, micronutrient gaps are common, though not as dramatic as in the bariatric surgery population