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Global transcriptional silencing is a highly conserved event from fully grown oocytes to zygotic genome activation (ZGA) at 48 cell embryo stage (Figure 3B), indicating that the effect of TRIP13 variants was initiated during oocyte growth

revealed that copper specifically binds to lipoylated proteins of the tricarboxylic acid cycle, leading to cellular proteotoxicity and consequent cell death

These results position Epitalon as a potential candidate for stabilizing cholinergic tone, a critical early disruption in age-related cognitive decline, and for addressing cognitive disorders associated with cholinergic deficiency and amyloid metabolism

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