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Age-related anabolic resistance diminishes the muscle-preserving effects of protein intake and exercise during weight loss [36]

When someone stops abruptly, their body can experience: A sudden return of appetite Increased cravings Higher blood sugar variability Faster gastric emptying Emotional rebound eating Research shows that rapid discontinuation is one of the strongest predictors of weight re-gain because appetite hormones spike back quickly, while lifestyle habits are still forming

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The American College of Gastroenterology recommends cholecystectomy (surgical gallbladder removal) for symptomatic cholelithiasis, which would typically be performed before considering weight loss pharmacotherapy