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Contrave may be a better fit for people with mild to moderate weight loss goals, those who prefer a daily pill, or individuals dealing with emotional eating or depression, as it may help curb cravings linked to brain reward signals

Mechanism of action : Both mimic a natural hormone in your body called GLP-1, increase insulin, decrease glucagon to prevent liver sugar production, slow gastric emptying, and target GLP-1 receptors in the brain to reduce appetite and increase feelings of fullness

In clinical trials, participants who saw the best results with semaglutide also received support to improve their diet and increase their physical activity

Patent protection for semaglutide is expiring in India around March 2026 , allowing Indian pharmaceutical companies to produce branded generic versions