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Collectively, the STEP program and related studies show: Average weight loss of around 1517% of initial body weight over about 68 weeks with semaglutide 2.4 mg once weekly, alongside lifestyle changes

Maintaining a consistent, regular dosing schedule helps support appetite control, blood sugar stability, and steady progress toward significant weight loss goals.

Other potential side effects can include: Diarrhea Constipation Abdominal (stomach) pain Headache Fatigue Dyspepsia (indigestion) Dizziness Abdominal distension Eructation or belching Hypoglycemia (low blood sugar) in patients with type 2 diabetes Flatulence Gastroenteritis (an intestinal infection) Gastroesophageal reflux disease (a type of digestive disorder)

And any caloric deficit, regardless of how it is created (medication, surgery, dieting, illness), causes the body to tap into both fat stores and lean tissue for energy