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Both the DJ-1 and LRRK2 proteins are associated with the autophagy-lysosome pathway, maintaining a role in mitochondrial and lysosomal function while being essential for maintaining normal cellular function and survival (Lizama and Chu, 2021)

This interaction may lead to suboptimal thyroid hormone levels, even in patients who are otherwise compliant with therapy

This tier has the strongest human clinical data, with large randomized controlled trials reporting body weight reductions that dwarf any other class of fat loss compound in history

Sharma A, Ambrosy AP, DeVore AD, Margulies KB, McNulty SE, Mentz RJ, Hernandez AF, Michael Felker G, Cooper LB, Lala A