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Mitochondrial metabolism has also been suggested to be critical to NK function

One in three women undergoing axillary lymph node dissection and radiotherapy will develop this incurable and disabling disease ( As far back as 1957 studies have shown that obesity can increase the risk of secondary lymphedema ( Glucagon-like peptide 1 receptor agonists (GLP-1RAs) were originally brought to market as treatments for diabetes, and were noted to induce weight loss ( Although weight loss has been reported to be beneficial in the treatment of lymphedema, no studies to date have examined the use of GLP-1RAs for the treatment of secondary lymphedema

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doi: 10.1016/j.cgh.2006.03.020 164 MorrowDMFitzsimmonsPEChopraMMcGlynnH