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HE4 will be low in patients with endometriosis Treatment: Watchful waiting : if no symptoms and the cyst does not appear suspicious, you can repeat the ultrasound in 6 wks to see if it will stay the same, resolve or grow If tumor markers are elevated: surgery to remove the cyst or the ovary If the cyst is greater than 5cm: more likely to require surgery because of the risk of ovarian torsion.