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Yet, based on the available studies, semaglutide appears to be more effective in improving glycemic control, as measured by the reduction in the levels of glycated hemoglobin (HbA1c): According to data from the SUSTAIN-FORTE trial, there was a -2.2% reduction in baseline HbA1c with 2mg/weekly semaglutide and 1.9% reduction with 1mg/weekly semaglutide after 40 weeks [21] The AWARD-11 trial revealed a -1.77% reduction in baseline HbA1c with 4.5mg/weekly dulaglutide after 36 weeks [18]

Without enough B6, this pathway stalls and glutathione synthesis slows down

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