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It is estimated to impact around 5-15% of women in their reproductive years ( In 1925, Sampson first outlined the diagnostic criteria for EAOC ( 2 Pathogenesis of EAOC 2.1 Abnormal expression of related genes Multiple studies suggest that ARID1A may act as a tumor suppressor ( Furthermore, the lack of p53 has been observed to lead to an exaggerated proliferation of endometrial glands ( Multiple studies have provided evidence of an increase in the copy number of the CCNE1 gene and an up-regulation of CCNE1 in ovarian clear cell carcinoma

6, June 2007, pp

Therefore, it is best to consult a healthcare provider while you are pregnant or breastfeeding

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