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If I take it at the beginning of the night, it reduces my deep slow wave sleep and gives me far more REM across the night

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Recent research indicates that Spirulina supplementation might offer neuroprotective benefits and enhance cognitive performance in neurodegenerative disorders, including Alzheimer's and Parkinson's disease ( 3.7 The role of Spirulina in gut health Changes in intestinal microbiota and disruptions in gene expression and metabolic enzyme activity appear to negatively affect intestinal functions (104)

Bottom line: For the best results, take liposomal versions of both vitamin C and glutathione on an empty stomach in the morning to maximize cellular uptake