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One should consider the primary phase lesion and hemorrhaging that results from mechanical damage during SCI as well as the secondary phase lesion that lasts several hours or even several months and is accompanied by edema, hemorrhage, inflammation, and cytotoxic edema [44,45,46,47] and may extend to the white matter area and lead to white matter degeneration and damage [48, 49]

The difference between 1 unit and 2 units represents a 100% change in dose, from 200 mcg to 400 mcg

A safe and effective subcutaneous injection in the lumbar region should be administered about 1-2 inches away from the spine

Antacids may decrease the absorption of steroids and this may require dose adjustment, especially in patients receiving low doses