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Animal studies showing gut effects used oral doses roughly in the range of 10 mcg per kg body weight

Conjugation of TLR2 Pep to Maleimide Doped Oridonin-Liposome A cysteine (Cys) residue was synthetically appended to the C-terminal of the TLR2 targeting peptide, resulting in an amino acid sequence represented as His-Leu-Tyr-Val-Ser-Pro-Trp-Cys

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The mechanisms of BoNT/A include reducing reactive oxygen species (ROS) and iron ion accumulation, restoring mitochondrial function, and activating the SLC7A11/GPX4 anti-ferroptotic pathway (Zeng et al., 2024)